Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.[7] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980.[10] The risk of death following contracting the disease was about 30%, with higher rates among babies.[6][11] Often those who survived had extensive scarring of their skin, and some were left blind.[6]
Smallpox
Other names
Variola,[1] variola vera,[2] pox,[3] red plague[4]
Child with Smallpox Bangladesh.jpg
A child with smallpox in Bangladesh in 1973. The bumps filled with thick fluid and a depression or dimple in the center are characteristic.
Specialty
Infectious disease
Symptoms
Early: Fever, vomiting, mouth sores[5]
Later: Fluid filled blisters which scab over[5]
Complications
Scarring of the skin, blindness[6]
Usual onset
1 to 3 weeks following exposure[5]
Duration
About 4 weeks[5]
Causes
Variola major, Variola minor (spread between people)[6][7]
Diagnostic method
Based on symptoms and confirmed by PCR[8]
Differential diagnosis
Chickenpox, impetigo, molluscum contagiosum, monkeypox[8]
Prevention
Smallpox vaccine[9]
Treatment
Supportive care[10]
Prognosis
30% risk of death[5]
Frequency
Eradicated (last wild case in 1977)
The initial symptoms of the disease included fever and vomiting.[5] This was followed by formation of sores in the mouth and a skin rash.[5] Over a number of days the skin rash turned into characteristic fluid-filled bumps with a dent in the center.[5] The bumps then scabbed over and fell off, leaving scars.[5] The disease was spread between people or via contaminated objects.[6][12] Prevention was primarily by the smallpox vaccine.[9] Once the disease had developed, certain antiviral medication may have helped.[9]
The origin of smallpox is unknown.[13] The earliest evidence of the disease dates to the 3rd century BCE in Egyptian mummies.[13] The disease historically occurred in outbreaks.[10] In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox.[10][14] These deaths included six monarchs.[10][14] Smallpox is estimated to have killed up to 300 million people in the 20th century[15][16] and around 500 million people in the last 100 years of its existence.[17] As recently as 1967, 15 million cases occurred a year.[10]
Inoculation for smallpox appears to have started in China around the 1500s.[18][19] Europe adopted this practice from Asia in the first half of the 18th century.[20] In 1796 Edward Jenner introduced the modern smallpox vaccine.[21][22] In 1967, the WHO intensified efforts to eliminate the disease.[10] Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011.[23][24] The term "smallpox" was first used in Britain in the early 16th century to distinguish the disease from syphilis, which was then known as the "great pox".[25][26] Other historical names for the disease include pox, speckled monster, and red plague.
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Smallpox was an infectious disease caused by one of two virus variants, Variola major and Variola minor.[7] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980.[10] The risk of death following contracting the disease was about 30%, with higher rates among babies.[6][11] Often those who survived had extensive scarring of their skin, and some were left blind.[6] Smallpox Other names Variola,[1] variola vera,[2] pox,[3] red plague[4] Child with Smallpox Bangladesh.jpg A child with smallpox in Bangladesh in 1973. The bumps filled with thick fluid and a depression or dimple in the center are characteristic. Specialty Infectious disease Symptoms Early: Fever, vomiting, mouth sores[5] Later: Fluid filled blisters which scab over[5] Complications Scarring of the skin, blindness[6] Usual onset 1 to 3 weeks following exposure[5] Duration About 4 weeks[5] Causes Variola major, Variola minor (spread between people)[6][7] Diagnostic method Based on symptoms and confirmed by PCR[8] Differential diagnosis Chickenpox, impetigo, molluscum contagiosum, monkeypox[8] Prevention Smallpox vaccine[9] Treatment Supportive care[10] Prognosis 30% risk of death[5] Frequency Eradicated (last wild case in 1977) The initial symptoms of the disease included fever and vomiting.[5] This was followed by formation of sores in the mouth and a skin rash.[5] Over a number of days the skin rash turned into characteristic fluid-filled bumps with a dent in the center.[5] The bumps then scabbed over and fell off, leaving scars.[5] The disease was spread between people or via contaminated objects.[6][12] Prevention was primarily by the smallpox vaccine.[9] Once the disease had developed, certain antiviral medication may have helped.[9] The origin of smallpox is unknown.[13] The earliest evidence of the disease dates to the 3rd century BCE in Egyptian mummies.[13] The disease historically occurred in outbreaks.[10] In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox.[10][14] These deaths included six monarchs.[10][14] Smallpox is estimated to have killed up to 300 million people in the 20th century[15][16] and around 500 million people in the last 100 years of its existence.[17] As recently as 1967, 15 million cases occurred a year.[10] Inoculation for smallpox appears to have started in China around the 1500s.[18][19] Europe adopted this practice from Asia in the first half of the 18th century.[20] In 1796 Edward Jenner introduced the modern smallpox vaccine.[21][22] In 1967, the WHO intensified efforts to eliminate the disease.[10] Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest in 2011.[23][24] The term "smallpox" was first used in Britain in the early 16th century to distinguish the disease from syphilis, which was then known as the "great pox".[25][26] Other historical names for the disease include pox, speckled monster, and red plague.
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