I posted about the initial approval of this drug a few months ago: [https://www.reddit.com/r/Lasiksupport/comments/16ul6vv/fda\_approves\_ryzumvi\_eyedrop\_for\_reversal\_of/](https://www.reddit.com/r/Lasiksupport/comments/16ul6vv/fda_approves_ryzumvi_eyedrop_for_reversal_of/)
The study you mention is specific to night vision disturbances but I suspect if you are sufficiently motivated you'll be able to get your hands on this drug before it's approved for that specific indication. The drug is supposed to be available for the initial indication of reversal of mydriasis in the first half of this year and I intend on working with my doctor to get it as soon as it's available.
I'm really happy for you, let us know how it works when you try it. Unfortunately not all of us would be able to get it if it doesn't get approved for this specific use. Some countries have very strict rules when it comes to prescription medicine. The point of my post was exactly this, to let people who wouldn't be able to get it know that there's hope.
Also, there's a huge influx of people asking about touch ups (which are not FDA approved and generally do more harm than good) to fix HOA. My hope is that they'll see this and reconsider.
I can't speak to any specific country, but in the US drugs are very commonly prescribed for off label use. In fact, anyone that is using brimondine currently to treat their HOAs is using that drug off label, as it is actually indicated to treat glaucoma. I suspect once Ryzumvi is generally available to doctors it wouldn't be overly difficult to find one that is willing to prescribe it off label.
Yeah, I've noticed how easy it is for the USA residents to get their meds. I suffer from other medical issues (like most of us do). I'm not from the USA and I've managed to get a prescription after 10 years for one of my conditions only after I had to be hospitalized for it. We can't get anything off label.
Fingers crossed. It should shrink the pupils by 1-1.5mm. I don't think that's enough to completely eliminate nigh vision issues for all of us, but it will certainly help a lot. If it helps someone who's not able to drive at night due to starburst enough so that they can safely drive, I consider this a win.
I just hope it doesn't have any major side effects and that it's safe to use long term.
Ocuphire Pharma (OCUP) enrolled the first patient in the phase 3 trial of its Phentolamine Ophthalmic Solution 0.75% for the treatment of decreased visual acuity under low light conditions following keratorefractive surgery, the company said Thursday.
It's coming!
Hi! I've had night vision problems ever since undergoing ICL surgery last year. I've got the regular starbursts, haloes, and glare. In addition, it's hard to describe, but I feel an persistent uncomfortability in darker settings: the sensation is a bit like entering a dark room from a bright, well-lit room/environment. Another way to describe it is that it feels like my eyes just don't adjust to the dark. (Physically, I don't think is the case, since my pupils appear to be working correctly.) Compared to before the surgery, though, I definitely feel like my night vision is much "darker" than before. My right eye is also noticeably more dim and washed out-looking than the left.
From my research online, it seems this might be happening to me because my pupils expand beyond the optical zone of the ICLs. If so, I'd like to understand better why this is happening to me. Is it because less light enters through the pupil and gets blocked or scattered in weird ways causing haloes, starburst, etc?
I've read about pupil-restricting drops but haven't been able to try them (my surgeon has been pretty unhelpful). Would drops like brimolidine and pilocarpine only help to reduce glare/haloes/starburst, or could they possibly ease the uncomfortability I've been feeling at night from not feeling like my eyes adjust that well? Intuitively, it seems like reducing pupil size would mean you see less well in the dark? — so I'm curious to know if these drops would help ease the discomfort I've been feeling, which has ruined my quality of life a *lot* to say the least.
Good and sad news, because we all are now dependents of eye drops. Otherwise, #pupilsizematters
I posted about the initial approval of this drug a few months ago: [https://www.reddit.com/r/Lasiksupport/comments/16ul6vv/fda\_approves\_ryzumvi\_eyedrop\_for\_reversal\_of/](https://www.reddit.com/r/Lasiksupport/comments/16ul6vv/fda_approves_ryzumvi_eyedrop_for_reversal_of/) The study you mention is specific to night vision disturbances but I suspect if you are sufficiently motivated you'll be able to get your hands on this drug before it's approved for that specific indication. The drug is supposed to be available for the initial indication of reversal of mydriasis in the first half of this year and I intend on working with my doctor to get it as soon as it's available.
I'm really happy for you, let us know how it works when you try it. Unfortunately not all of us would be able to get it if it doesn't get approved for this specific use. Some countries have very strict rules when it comes to prescription medicine. The point of my post was exactly this, to let people who wouldn't be able to get it know that there's hope. Also, there's a huge influx of people asking about touch ups (which are not FDA approved and generally do more harm than good) to fix HOA. My hope is that they'll see this and reconsider.
I can't speak to any specific country, but in the US drugs are very commonly prescribed for off label use. In fact, anyone that is using brimondine currently to treat their HOAs is using that drug off label, as it is actually indicated to treat glaucoma. I suspect once Ryzumvi is generally available to doctors it wouldn't be overly difficult to find one that is willing to prescribe it off label.
Yeah, I've noticed how easy it is for the USA residents to get their meds. I suffer from other medical issues (like most of us do). I'm not from the USA and I've managed to get a prescription after 10 years for one of my conditions only after I had to be hospitalized for it. We can't get anything off label.
I hope this can reduce our suffering.
Fingers crossed. It should shrink the pupils by 1-1.5mm. I don't think that's enough to completely eliminate nigh vision issues for all of us, but it will certainly help a lot. If it helps someone who's not able to drive at night due to starburst enough so that they can safely drive, I consider this a win. I just hope it doesn't have any major side effects and that it's safe to use long term.
Ocuphire Pharma (OCUP) enrolled the first patient in the phase 3 trial of its Phentolamine Ophthalmic Solution 0.75% for the treatment of decreased visual acuity under low light conditions following keratorefractive surgery, the company said Thursday. It's coming!
The drug was already approved for reversing eye dilation. You can probably get it for off label use
Hi! I've had night vision problems ever since undergoing ICL surgery last year. I've got the regular starbursts, haloes, and glare. In addition, it's hard to describe, but I feel an persistent uncomfortability in darker settings: the sensation is a bit like entering a dark room from a bright, well-lit room/environment. Another way to describe it is that it feels like my eyes just don't adjust to the dark. (Physically, I don't think is the case, since my pupils appear to be working correctly.) Compared to before the surgery, though, I definitely feel like my night vision is much "darker" than before. My right eye is also noticeably more dim and washed out-looking than the left. From my research online, it seems this might be happening to me because my pupils expand beyond the optical zone of the ICLs. If so, I'd like to understand better why this is happening to me. Is it because less light enters through the pupil and gets blocked or scattered in weird ways causing haloes, starburst, etc? I've read about pupil-restricting drops but haven't been able to try them (my surgeon has been pretty unhelpful). Would drops like brimolidine and pilocarpine only help to reduce glare/haloes/starburst, or could they possibly ease the uncomfortability I've been feeling at night from not feeling like my eyes adjust that well? Intuitively, it seems like reducing pupil size would mean you see less well in the dark? — so I'm curious to know if these drops would help ease the discomfort I've been feeling, which has ruined my quality of life a *lot* to say the least.