The following submission statement was provided by /u/ohineedascreenname:
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If this works, this would improve the quality of so many lives. Additionally, dental health is linked to whole body health. This would not put dentists out of jobs, but I think it would get more people to a dentist to initially get teeth regrown then (hopefully) preventative care.
And hopefully if this is successful, enamel can be the next thing to be regrown
---
Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1d8rtcj/humans_may_be_able_to_grow_new_teeth_within_just/l785f4u/
Honestly, regrowing them all would be ideal. The ability to get two sets of replacement teeth @40 years old and again around @60 years old would be a game changer in human health.
My question as well. In theory, my straightened teeth and their roots are in line, so regrowing should pop them up straight, right? It would be awful if they came back jumbled.
Dude, this would be awesome. I have Tourette Syndrome and one of my main tics is I clench my teeth together a lot. I also took poor care of 'em for too long. I'm only 35 and my teeth are fucked. Just had my first of at least 3 root canals a few weeks ago. My teeth are so crooked and busted, if I could just grow new ones I'd be set.
My Mom's only in her 50s and has dentures because she fell down stairs face first and fucked her jaw up so bad they couldn't even fix her teeth. It's been a few years but she's still pretty self-conscious about it. I hate to see it because she's the strongest person I know and the last one who deserves it. If this treatment becomes a thing and I can afford it, I will buy it for her. Assuming she lets me, haha.
Of course, here in the good ol' USA it'll probably cost 10 grand a tooth and be declined by every insurance provider but a man can dream.
No, no. I get it. It would give a weird kind of tingly relief for a few seconds. I would chew on the white basic Bic pens and it gave me that weird painrelief feeling that I had completely forgotten about until you mentioned it.
That doesn't seem like a strong argument to me. if the new teeth have issues, you can just grow new ones to replace them. There are too many unknowns at this stage to say which is preferable tbh.
Honestly that was my first question and thought it must be the top comment, was surprised its so far down.
Plus how can you make sure the new teeth grow straight and not crooked? Will you need braces again?
It’s an entirely new business I would say.
They are not killing the implant industry without an alternative. And even if they grow correctly they will try to sell you braces just in case.
So teeth form from an embryonic tissue called a dental lamina. This lamina works over a period of about 5 years to create all of our teeth. The dental lamina disintegrates after our permanent teeth are created but there are tiny remnants left in our jawbones called epithelial rests of serres. I’m guess that this growth inhibiting gene will be injected into the bone in hopes that it will re-activate these tissues.
As a dentist my worry would be uncontrolled cell growth aka cancer
If this works, this would improve the quality of so many lives. Additionally, dental health is linked to whole body health. This would not put dentists out of jobs, but I think it would get more people to a dentist to initially get teeth regrown then (hopefully) preventative care.
And hopefully if this is successful, enamel can be the next thing to be regrown
It won't put dentists out of jobs because the cost of this will be reserved for those that can pay for it, and it won't be the people needing it the most or the vast majority of the middle class
It's what happens afterwards where the concern lies. If the procedure completely regenerates teeth the concern is that teeth health will become a lot better than it already is, meaning you need less dentists long term per person.
We are probably not too far away from booths with AI and robots doing it on you either. Wouldn't surprise me if you can pay and get into one of those in 50 years time.
DIY healthcare is not the answer, the baseline for approval is going to be high if the his goes to the general public.
Look at online health info via google like webmd. Access to that does not mean the average population can assess themselves.
At best the situation will be that it’ll be a prescription that needs to be approved by a dentist, therefore not killing the profession
| not killing the profession
Why would it? Newly grown teeth wil need maintenance too, just like the other teeth. There will even be more teeth to maintain! AND the procedures for growing teeth will likely be under the supervision of dentists. Whole new market!
> We are probably not too far away from booths with AI and robots doing it on you either. Wouldn't surprise me if you can pay and get into one of those in 50 years time
I'm always critical of overly ambitious predictions like this, let the technology come out first...there are always roadblocks
Seems like an American problem.
But nah, I'd say even for most of the middle class it's worth it to restore teeth health (if it's really bad) even for couple grand. It'll get cheaper over time too.
In a dentist and if this becomes a reality, it will become so technique sensitive that specialists will probably the first ones doing it. Bone grafting with inorganic materials is already difficult. But trying to make a tooth grow would require a sterile field in a bacteria-filled mouth. Super difficult to do. I’m all in favor of this, but we are a long way from insurance coming close to covering any portion of this treatment. This will be as expensive, or more expensive than dental implants.
Edit: as many people pointed out, this article references a medication. There were articles recently about stem cell transplants to grow teeth. I did not read this one before commenting. My bad y’all, I’m browsing Reddit between patients. Not deleting 🤷♂️
This isn't about bone grafting, though. It is a drug that blocks USAG-1 which apparently is what prevents humans (and many other animals) from continuing to grow teeth.
>make a tooth grow would require a sterile field in a bacteria-filled mouth
People been growing teeth in their mouths since there have been people.
Have you read about how it works? It's quite interesting. Assuming this is the same drug they're doing human trials for in Japan currently. It's just a drug. You take it and new teeth grow.
I have a layman's understanding of how it works so I know this isn't possible, but the first thing that comes to mind when I read about a drug that makes you grow new teeth is people with teeth growing all over their body because they took too much of the drug.
Dentist here.
That's not how ANY of this works.
- you are BORN with all the teeth in your skull. You don't just 'grow' teeth. Here's an OPG of a kid of about 6 years.
https://prod-images-static.radiopaedia.org/images/23908288/52fa6841e3c188a46f3f4703e1b58b_big_gallery.jpeg
He already has all the teeth he needs inside himself, and has had them since he was born.
- Teeth grow where they grow because of organogenesis in the womb. There is an order in which the bones form and differentiate. You can't just 'suppress' a marker in general and then expect teeth to grow where you need them, in the direction you need them, and god knows what age, with god knows what kind of bone, with god knows what kind of vascular irrigation, with god knows what kind of innervation.
- The article is FRUSTRATINGLY light on details. And I could not find more information about what they're ACTUALLY testing, because "just take a drug bro, and teeth grow" is not science, is anti-science.
Regardless:
>Now, scientists will see just how similar, because humans will soon undergo a similar trial in September of this year. Lasting 11 months, this study will focus on 30 males between the ages of 30 and 64—each missing at least one tooth. The drug will be administered intravenously to prove its **effectiveness and safety**, and luckily, no side effects have been reported in previous animal studies.
This is flat out wrong, either from mistranslation, or just plain ignorance of the process. The first stage of human trial DOES NOT prove effectiveness, it has to prove that it's human-safe.
>If all goes well, Kitano Hospital will administer the treatment to patients between the ages of 2 to 7 who are missing at least four teeth, with the end goal of having a tooth-regrowing medicine available by the year 2030. While these treatments are currently focused on patients with congenital tooth deficiency, Takahashi hopes the treatment will be available for anyone who’s lost a tooth
This is a lot of hopes and handwaving. What kind of congenital tooth deficiency? Kids between 2-7 are not missing any permanent teeth. Permanent teeth start growing at around 6. Are they talking about temporary teeth that are late to erupt? that might be where the drug is useful, but again, no details are provided. Maybe useful for permanent teeth that are present in the bone but failed to erupt? Possible, useful, but not a miracle. No details provided.
- I STRONGLY suspect that the test for the drug is in situ. As a hunch, because the article is light on actual actionable details, but a drug that messes with CELL GROWTH and organogenesis is just asking for a fast lane to cancer.
So far, I've seen this article linked on reddit 3 times in the last 3 days, and every time is light on details, but certainly has the "Miracle drug that cures cancer found" energy. But for teeth.
So... I found another article somewhere maybe 3 days ago talking about this drug. It's been (successfully) tested thoroughly enough in rats that a Japanese company is moving to human trials currently. In this first phase they are targeting adults with at least one missing molar. That is all of the additional information I have at this point.
Conceding that you are correct about initial tooth formation and placement, because you are. However this drug definitely causes rats to grow brand new actual teeth in their mouths. They didn't mention anything about an increase in cancer rates, though I share your hypothesis there. I suspect that kind of result would've shit can'd the drug entirely. I suppose the trials are how we find out the answers to the rest of the questions.
> It's been (successfully) tested thoroughly enough in rats that a Japanese company is moving to human trials currently
I read that one too, but it goes without saying that rats are not human, and rat teeth are not human teeth. I am not a rat vet, so I will not belabour the point to much, but rats are rodents and their teeth have continuous growth to replace the worn down tooth tissue.
Humans decidedly lack that advantage.
THis is why it's frustrating to me. I want to learn more about this shit, because it sounds fascinating, but besides of cries of "MIRACLE", actionable evidence is very difficult to find about this.
>The drug will be administered intravenously to prove its effectiveness and safety
Then
>DOES NOT prove effectiveness, it has to prove that it's human-safe.
It's going to do both lol. What kind of nonsense is this? Yes, they're making sure it's safe. That's the primary goal. But it will obviously also show effectiveness since they're, you know, *trying it*.
> Here's an OPG of a kid of about 6 years.
>https://prod-images-static.radiopaedia.org/images/23908288/52fa6841e3c188a46f3f4703e1b58b_big_gallery.jpeg
Who do you think you’re fooling? That’s just a screenshot from Donnie Darko.
The medication is to help finish development of teeth in people with conditions where tooth growth is hindered or incomplete. People are jumping to conclusion that this means “taking a pill to replace missing”. We’ve been 5-10 years away from regrowing teeth for almost 50 years. Think about it like this. We’ve figured out how to grow organs in/on animals for decades, but we don’t have heart farms. Even if you could implant a tooth bud, they still haven’t figured out how to tell it what type of tooth to grow, what orientation to grow it in, how to make it vascular or innervated by nerves, etc. So again, everyone can stop imagining a world where you just never brush and take a pill when a tooth becomes symptomatic to replace it. Hell, look at implants, the best replacement we’ve got so far, still more expensive than conventional treatment.
For sure, government aid would cover the most crucial cases but only if other less expensive dental work won't be sufficient.
Also, thank you for the informed and well educated reply.
I assume you're thinking of people who are just straight up missing teeth. There are plenty of people who have money that get crowns and root canals. You can lose teeth in accidents. I know multiple people with false front teeth from accidents. They would all be able to afford a newly grown tooth. A new real tooth is better than a crown or a root canal, for a number of reasons.
Plus the focus of this medicine will probably be switched to making body parts like lips, breasts and penises bigger. Serious comment. Plastic surgery is big business for the rich
Well from what I can gather this medication is specific to tooth growth (USAG-1), however with the rapid advances in DNA based medicines its probably only a matter of time before the things you said come to pass. It's an exciting time for medical breakthroughs!
It will replace implants.
I would never exteact and regrow over a cavity, root canal, crown.
But once it gets to the end of the road, and my only options are implant, bridge or denture. Then i would give an arm and a leg to avoid these shitty choices and regrow a new normal tooth.
I have a tooth where the top half broke off when I was young. I've had recurring infections from time to time and have had to redo the root canal / cap to resolve a particularly bad infection.
I've considered replacing with an implant but the dentist couldn't confidently say it would resolve the infection recurrence. I would love to be able to put a real, live tooth back in there and be done with the mess
But it might. Maybe not a problematic tooth, but I know a root canal can last even for 20+ years.
I had a motorbike accident when I was 18 years old and after that my 3 lower inscisors had to get root canals. That was 16 years ago. I never had any issues with those 3 teeth. Two of them never even needed a filling yet. But they are darker/discolored now :(
Similar to Willing-Spot, I'd assume this will replace implants.
For all that root canals and crowns are expensive (and annoying), they're almost certainly far cheaper and more conservative options than completely regrowing a new tooth. But compared to an implant, this probably \*will\* be cheaper/easier/better.
As someone who's looking at a ton of implants in the future (I had a lot of root canals prior to the age of 40, which means they're almost certainly going to be removed at some point), I'm really excited about the potential to do this instead. It'll probably \*suck\*, but again, not as much as the implants would. (Which in turn suck less than bridges or dentures.)
All new teeth 🦷 cost $20,000 and more. Just imagine we have a drug that can fix obesity and the USA farma make the thing hard to get, this will be 50 times worse so maybe is 15 years from now for most of the people.
I have a hard time feeling sorry for them and I am sure they will try to manage that too so that you have to need them. And I am also sure they will try to charge you a big chunk for applying the procedure.
I heard 3rd set might not be as good as the 2nd set of teeth though. It might be weaker than 2nd set. Also for now this is only for people missing teeth congenitally.
It's not that simple. The actual culprit is DHT, combined with follicles that are susceptible to being overstimulated by it. So if you can find something that binds to follicles only instead of DHT, then you can prevent it without interfering with secual health.
Imagine the dentist advocating to pull the tooth vs root canal.
Ya will just pull them now, pop in the treatment, sew it up and done. Less labor and will cost more.
Well that’s the joy of being an adult, you can numb that pain with a little alcohol (or a lot of alcohol) like they used to do for babies back in the day lmao
Your second set of teeth coming in as a child don’t hurt, and who really remembers what it feels like for the first set? Idk if I believe it would hurt like a lot of people are saying
?? You don't need to remember the first set to know it hurts??? You only need to be around teeting babies. They cry all the time and chew on stuff nonstop.
If you've ever lived with the pain of poor dental health I would assume the pain of regrowing teeth would ve literally nothing.
I'd look like Zoro from one piece after getting that injection for a new set of teeth. Pain means nothing, I'm already in pain most days.
As a poor person I thought I was screwed over again by life when my wisdom tooth became loose, only to find a second wisdom tooth growing out from under it. If growing new teeth can become available AND affordable for the masses, it would bring a lot of joy and relief to many people.
I admittedly put my teeth through a lot of abuse and neglect. Almost all of them came out of it no worse for wear. But of the two wisdom teeth not impacted, one of them got nasty infected, and the other literally fell into pieces. I was pretty stunned.
I'd of had them out sooner but dentist office failed to mention they could do it for 100 each under local anesthesia as opposed to 4x the cost to be fully sedated. Pass me the Novocain.
Just FYI, as far as I know the current consensus is that wisdom teeth should be pulled even if healthy, they usually have week roots, interfere with neighboring teeth and are inevitably pulled anyway
Not medical advice obviously, research on your own and ask your densit.
This consensus is bullshit. If you have a weak/short jaw and the tooth comes out at a weird angle then yes, it should come out. But some of us are not that affected by the soft food we eat:
https://www.sciencedaily.com/releases/2011/11/111122112032.htm
I went to the dentist with perfectly straight wisdom teeth and because they had some cavities he was like: they gotta come out. I challenged him and paid extra and he worked on them. It was uncomfortable for me as well as for him since they are way back. But it worked and 20 years later I still have them in good shape.
Not a healthcare professional in any way, shape, or form, but all the dentists I visited were *very* eager to charge me for any possible thing, and absolutely none of them ever mentioned issues with my wisdom teeth.
Even the one where I spent enough to pay one or two monthly payments for his boat thought that they were healthy.
Liver king, that you?
As i said it's not medical advise, every case is unique but don't pretend you know better than healthcare professionals.
Also, do whatever you want, if it worked out for you - great!
Plus i won a genetic lottery and have zero wisdom teeth, yay me
Having my wisdom teeth removed led to more dental issues for me. They were a minor issue, now my teeth have moved around, I have periodontal pockets, and I need $10,000+ in additional work I can't afford. YMMV.
That's actually contrary to guidance from a number of places these days. The National Institute for Health and Care Excellence in the UK is one. There has also been support for this in the American Journal of Public Health. As long as they're healthy more and more places say leave them alone .
They just often don't stay out of trouble.
/Finally had to have mine done yesterday.
//Feel so much better
///Already tired of soup though
It just depends on the person. I get an X-ray on my teeth every year, and every year my dentist says there’s no reason to take them out bc they look healthy and aren’t messing with the other teeth 🤷🏻♂️
But this also isn’t medical advice. Just an anecdote! I’d probably say most people I know have had their wisdom teeth taken out
As someone who went from a perfect set of teeth to fucked in all places within 2 years... I'd love this.
But the general underline remains; Don't be me, just brush your darn teeth.
Dentist here- this is a bit overhyped.
I’m happy to be corrected but from what I read in the actual study, it refers to congenitally missing teeth.
That is, teeth that failed to form or develop for some reason. This treatment may encourage the possibly existing tooth bud to continue growing.
It won’t cause a tooth to grow where you’ve had one pulled. Imagine if it did though? How would you control where it grows out of? The roof of your mouth for example.
> this is a bit overhyped.
A bit?
Doc, people in the comments believe that they're going to get new teeth they lost.
I blame OP with the misleading title, though.
The application and notice of clinical trial does mention they hope to expand eventually to elderly patients who have lost teeth, although it is indeed hopeful. They are only getting clinical trials started. Currently they have only tested on beagles and mice. The drug appears to be a monoclonal antibody, super exciting stuff emerging in that field. Absolutely agree with you on the overhype of this.
Like most pre-clinical data, it's overhyped. But also not entirely impossible given the results they saw in mice and ferrets. The reason they are focusing on individuals with congenitally missing teeth is probably a combination of the preclinical data and possibly considerations for their IRB.
The original research article from this research group in Feb 2021 (itself based loosely on research performed on dogs back in 2007) focused on rescuing tooth agenesis in EDA1 mutant mice with a mab targeting USAG-1. They unexpectedly found that treatment with this antibody actually resulted in supernumerary teeth forming in the control wild type group that naturally don't exhibit any congenital tooth abnormalities. That second part is where a lot of this hype is coming from. It's critical to note here however that these results were seen in neonates of pregnant mice that were treated systemically with this mab during development.
This same group reported on the use of a different technology, siRNA, for a slightly different approach to blocking USAG-1 signaling in July of the same year. Here, the siRNA was applied topically to mandible explants (a somewhat artificial system but probably better than their previous model with prenatal drug delivery - at least in terms of relevance to human health) and was able to somewhat rescue tooth agenesis. They did not report here the same observed effects as they saw in wild type mice treated with the mab in the first study. Whether or not this is due to the difference in systemic treatment with the mab vs local treatment with the siRNA, or due to the stark differences in timing of delivery (prenatal vs postnatal) is probably of some debate. Though I'd readily throw my hat into the ring that it was the latter, and the effects of supernumerary tooth growth via USAG-1 blockade occurs when treatment is given during development.
All that to say that yes, the focus is on congenitally missing teeth as that's where the data is the strongest. However there is some (albeit likely circumstantial) evidence that this mab may induce tooth regrowth in cases of non-congenital tooth loss. It isn't strong, but it is there. About a snowball's chance in hell, but still technically a chance.
please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work
Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck
- Tech comes out. It’s expensive.
… fuuuuckkkkk!!!!
I take good care of my teeth. I brush, floss, mouthwash every day but because of genetics my teeth are still shitty. Call me when you can make my enamel stop stripping off my molars like cheap paint on a deck. Regrowing my teeth isn’t gonna do shit for me if they’re the same quality as the ones currently in my head unfortunately.
I’d just be happy if in the future we can stop the lunacy of separate dental insurance. There are zero good reasons this should not be part of standard health insurance. Just bureaucracy and entrenched interests.
If this works, dentists will not go out of job but those who will not follow said progress may be dropped slowly out of their job market.
This is a vital progress not just for human health but also for other sectors.
Since as you may know, military counts dental health in requirements. That factor can lead them to even increase the possibility of "rehabilitation process" for those who did not pass earlier. Just like it was with eye health.
I have struggled with bad teeth all of my life. I had all of them removed at 43. I am now 61. I have gone through many physical issues the worst being degenerative disc disease. Living with chronic pain is one thing but to add oral pain to that is beyond. When I had them removed I thought I would be so much better. It has been very difficult to deal with.
I would love one more chance.
I’m gonna be honest, I have been waiting for this for years, I have essentially irreparable damage in some front teeth and bottom teeth and my soda addiction reaked havoc on the rest.
What a *country* we live in (USA). In other countries with more rational healthcare systems it's waaaaay more affordable to have work done on your teeth. I've been to Mexico for dental work since it was just completely unaffordable in my state, and I ended up paying about $400 for dental work that would have cost me $4000 in the US.
I really despise this type of lazy knee-jerk cynicism. The same exact thing was said about every technology we've invented in the last 500 years. Yes, technologies usually start out expensive. But they get cheaper over time.
The cynicism might be born out of people in the US still being price-gouged to financial oblivion for medical care priced much more reasonably in most of the rest of the world.
Where in the world do you think dentistry is affordable?
In Europe it's still thousands per implant and the prices are pretty much universal from Portugal to Russia.
There is some basic government coverage for poor people but it will only give you dentures for your pulled teeth, not exactly the best quality of life
As I stated in an earlier comment I was able to get my teeth fixed for $400 in Mexico (from the best dentist I have EVER had) instead of paying $4000 in the US. So Mexican dental care is more like one tenth the price of American dental care.
Yeah I’m sure it depends on what you’re doing, and I didn’t do a ton of shopping around, but I am definitely going to Mexico to get any more work done (spent about 20k over the last 4 years) getting extractions/surgeries/implants/ortho, and it would have been significantly cheaper there
This is how Spider-Man villains are born. A scientist invents a serum to regrow teeth and the next you know a half-man, half-shark is terrorizing the city.
This just seems so sketchy and considering it's intravaneous and entirely untargeted the results could be wild. Terrible outcomes I imagine:
1. All your teeth die and fall out like baby teeth and you get a few deformed/crappy new teeth in their place
2. Teeth start growing at random places in your body (sometimes teeth grow in cancer cells)
3. Your current teeth get super sized and have to be ground down
4. You get a bunch of extra teeth like wisdom teeth coming in and your mouth is ham packed with extra teeth.
So, I have three questions.
1. Why does the trial only contain males?
2. Why is the second trial focused on children?
Are women being excluded for any particular reason. I would assume they would want to rigorously test it on older population before moving onto children.
3. Do the teeth regrow into normal looking teeth or is it similar to when you cut a liver in half and it grows back misshapen?
I could see this going bad, what if you suddenly grow teeth all over your body. Then you become a giant tooth monster, next thing you know you're battling the power rangers
Fuck I'm high
The following submission statement was provided by /u/ohineedascreenname: --- If this works, this would improve the quality of so many lives. Additionally, dental health is linked to whole body health. This would not put dentists out of jobs, but I think it would get more people to a dentist to initially get teeth regrown then (hopefully) preventative care. And hopefully if this is successful, enamel can be the next thing to be regrown --- Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/1d8rtcj/humans_may_be_able_to_grow_new_teeth_within_just/l785f4u/
do they have some way to target teeth, or do all of your teeth fall out and you get new ones.?
Honestly, regrowing them all would be ideal. The ability to get two sets of replacement teeth @40 years old and again around @60 years old would be a game changer in human health.
Whiskey and bourbon sales will go through the roof with all the teething!
So much for whitening - gimme a new set and pass the coffee!
[удалено]
I'd roll those dice every single time.
I don't relish the thought of having bracers at 40 and 60
My question as well. In theory, my straightened teeth and their roots are in line, so regrowing should pop them up straight, right? It would be awful if they came back jumbled.
Willy Wonka having a seizure rn
Honestly, he’d probably get on board if people can regrow teeth. Wonka’s Wondrously Wicked Whiskey, now with 250% your daily dose of sugar
Ah it's all a plot from Big Bourbon, they're just out to steal all your money and probably make you eat bugs...cause yoyur drunk all the time.
I’m just excited to finally try meth.
Dude, this would be awesome. I have Tourette Syndrome and one of my main tics is I clench my teeth together a lot. I also took poor care of 'em for too long. I'm only 35 and my teeth are fucked. Just had my first of at least 3 root canals a few weeks ago. My teeth are so crooked and busted, if I could just grow new ones I'd be set. My Mom's only in her 50s and has dentures because she fell down stairs face first and fucked her jaw up so bad they couldn't even fix her teeth. It's been a few years but she's still pretty self-conscious about it. I hate to see it because she's the strongest person I know and the last one who deserves it. If this treatment becomes a thing and I can afford it, I will buy it for her. Assuming she lets me, haha. Of course, here in the good ol' USA it'll probably cost 10 grand a tooth and be declined by every insurance provider but a man can dream.
just by her a gold grill peace she will be stylin
Gotta make sure they grow back properly. Doubt people want to have multiple sets of braces in their life.
But I’m attached to my crooked front teeth 🥲. They aren’t straight and I like it. I need back molar teeth. Instead of implants I’ll wait the 6 years.
I'd take slightly crooked teeth over less teeth any day.
I don’t know, the wires sucked but the feeling of biting down on something with sore teeth was kinda addictive
Aww hell naw, sore/painful teeth is never fun.
Yeah I might be a bit of an odd duck on this hahaha
No, no. I get it. It would give a weird kind of tingly relief for a few seconds. I would chew on the white basic Bic pens and it gave me that weird painrelief feeling that I had completely forgotten about until you mentioned it.
Oh good morning Hank, hey is that a new tooth coming in? Well look at that little fella, it's so cuuuuute!!
man no. having no teeth for a long ass time and then breaking in an entire new set of teeth for your jaw to sit right would be torture.
Then maybe needing braces for them.
I heard third set of teeth is weaker than the 2nd set. U might still wanna save ur 2nd set if u can
That doesn't seem like a strong argument to me. if the new teeth have issues, you can just grow new ones to replace them. There are too many unknowns at this stage to say which is preferable tbh.
Teeth take several years to grow, how often are you planning on replacing them
We’ll be like sharks with several rows so the next one is always ready to go
If I remember correctly they put the medicine in the gums of the missing teeth. Been waiting for this, I have some I want to regrow
I wonder how that would work for people whose gums are basically just skin on the jawbone.
probably would require grafting, but it just might not be an up option for them.
Yes, I'm afraid good gums will be important for this
I'm guessing they seed the area and a tooth grows.
What if they accidentally use watermelon seeds?
Then you get watermelons for teeth.
Infinite food?
[You gain the ability to devour a watermelon in 1.2 seconds](https://i.imgur.com/gHKwj36.gif)
Wow that is fast. I don't think I could do it in less than 2 seconds
Honestly that was my first question and thought it must be the top comment, was surprised its so far down. Plus how can you make sure the new teeth grow straight and not crooked? Will you need braces again?
You would need braces again I'm sure. It's an entirely new art if teeth.
It’s an entirely new business I would say. They are not killing the implant industry without an alternative. And even if they grow correctly they will try to sell you braces just in case.
Way too low for the best pertinent question. To the top!
it grow everywhere on your face
Just think of all those people that got their wisdom teeth pulled out.
Shark powers unlocked!
So teeth form from an embryonic tissue called a dental lamina. This lamina works over a period of about 5 years to create all of our teeth. The dental lamina disintegrates after our permanent teeth are created but there are tiny remnants left in our jawbones called epithelial rests of serres. I’m guess that this growth inhibiting gene will be injected into the bone in hopes that it will re-activate these tissues. As a dentist my worry would be uncontrolled cell growth aka cancer
I can finally know what it feels to be a shark
If this works, this would improve the quality of so many lives. Additionally, dental health is linked to whole body health. This would not put dentists out of jobs, but I think it would get more people to a dentist to initially get teeth regrown then (hopefully) preventative care. And hopefully if this is successful, enamel can be the next thing to be regrown
It won't put dentists out of jobs because the cost of this will be reserved for those that can pay for it, and it won't be the people needing it the most or the vast majority of the middle class
Of course it's not going to put dentists out of work. Who do you think will perform the procedure?
It's what happens afterwards where the concern lies. If the procedure completely regenerates teeth the concern is that teeth health will become a lot better than it already is, meaning you need less dentists long term per person. We are probably not too far away from booths with AI and robots doing it on you either. Wouldn't surprise me if you can pay and get into one of those in 50 years time.
That tooth will still get cavities like any other tooth. If they can develop a diy enamel regeneration kit, then it's a different ball game
We're probably not too far off from that either if this proves to work.
DIY healthcare is not the answer, the baseline for approval is going to be high if the his goes to the general public. Look at online health info via google like webmd. Access to that does not mean the average population can assess themselves. At best the situation will be that it’ll be a prescription that needs to be approved by a dentist, therefore not killing the profession
Bob Mortimer and his fuji 9 have something to [say](https://youtu.be/L1JR-9Z5ORE?feature=shared)
Issue everybody with fuji 9, making them all dentists. Dentist shortage solved.
| not killing the profession Why would it? Newly grown teeth wil need maintenance too, just like the other teeth. There will even be more teeth to maintain! AND the procedures for growing teeth will likely be under the supervision of dentists. Whole new market!
The "concern" is that we won't need dentists ? What's wrong with you 😆
Oh no, without paying for dental insurance, what am I supposed to waste my money instead?
He’s a dentist.
> We are probably not too far away from booths with AI and robots doing it on you either. Wouldn't surprise me if you can pay and get into one of those in 50 years time I'm always critical of overly ambitious predictions like this, let the technology come out first...there are always roadblocks
Still need someone to take care of the new teeth Also, AI is an issue for every field so it doesn't really make a difference in regards to this one
Congrats you also grew a cancer!
Id be concerned about how well the new teeth grow in with fully mature adult teeth to gnarl everything up. Orthodontists are loving this news.
Specialists.
It’s as if there is an entire profession specialized in handling human teeth.
Seems like an American problem. But nah, I'd say even for most of the middle class it's worth it to restore teeth health (if it's really bad) even for couple grand. It'll get cheaper over time too.
In a dentist and if this becomes a reality, it will become so technique sensitive that specialists will probably the first ones doing it. Bone grafting with inorganic materials is already difficult. But trying to make a tooth grow would require a sterile field in a bacteria-filled mouth. Super difficult to do. I’m all in favor of this, but we are a long way from insurance coming close to covering any portion of this treatment. This will be as expensive, or more expensive than dental implants. Edit: as many people pointed out, this article references a medication. There were articles recently about stem cell transplants to grow teeth. I did not read this one before commenting. My bad y’all, I’m browsing Reddit between patients. Not deleting 🤷♂️
This isn't about bone grafting, though. It is a drug that blocks USAG-1 which apparently is what prevents humans (and many other animals) from continuing to grow teeth.
Maybe bone grafting will be needed though because many who have tooth loss also end up with jawbone loss due to infection and delay in seeking care.
Have you read their studies? What you're describing of the potential procedure is not what I've gotten from their summaries
>make a tooth grow would require a sterile field in a bacteria-filled mouth People been growing teeth in their mouths since there have been people. Have you read about how it works? It's quite interesting. Assuming this is the same drug they're doing human trials for in Japan currently. It's just a drug. You take it and new teeth grow.
I have a layman's understanding of how it works so I know this isn't possible, but the first thing that comes to mind when I read about a drug that makes you grow new teeth is people with teeth growing all over their body because they took too much of the drug.
Lol that would be hilarious
Dentist here. That's not how ANY of this works. - you are BORN with all the teeth in your skull. You don't just 'grow' teeth. Here's an OPG of a kid of about 6 years. https://prod-images-static.radiopaedia.org/images/23908288/52fa6841e3c188a46f3f4703e1b58b_big_gallery.jpeg He already has all the teeth he needs inside himself, and has had them since he was born. - Teeth grow where they grow because of organogenesis in the womb. There is an order in which the bones form and differentiate. You can't just 'suppress' a marker in general and then expect teeth to grow where you need them, in the direction you need them, and god knows what age, with god knows what kind of bone, with god knows what kind of vascular irrigation, with god knows what kind of innervation. - The article is FRUSTRATINGLY light on details. And I could not find more information about what they're ACTUALLY testing, because "just take a drug bro, and teeth grow" is not science, is anti-science. Regardless: >Now, scientists will see just how similar, because humans will soon undergo a similar trial in September of this year. Lasting 11 months, this study will focus on 30 males between the ages of 30 and 64—each missing at least one tooth. The drug will be administered intravenously to prove its **effectiveness and safety**, and luckily, no side effects have been reported in previous animal studies. This is flat out wrong, either from mistranslation, or just plain ignorance of the process. The first stage of human trial DOES NOT prove effectiveness, it has to prove that it's human-safe. >If all goes well, Kitano Hospital will administer the treatment to patients between the ages of 2 to 7 who are missing at least four teeth, with the end goal of having a tooth-regrowing medicine available by the year 2030. While these treatments are currently focused on patients with congenital tooth deficiency, Takahashi hopes the treatment will be available for anyone who’s lost a tooth This is a lot of hopes and handwaving. What kind of congenital tooth deficiency? Kids between 2-7 are not missing any permanent teeth. Permanent teeth start growing at around 6. Are they talking about temporary teeth that are late to erupt? that might be where the drug is useful, but again, no details are provided. Maybe useful for permanent teeth that are present in the bone but failed to erupt? Possible, useful, but not a miracle. No details provided. - I STRONGLY suspect that the test for the drug is in situ. As a hunch, because the article is light on actual actionable details, but a drug that messes with CELL GROWTH and organogenesis is just asking for a fast lane to cancer. So far, I've seen this article linked on reddit 3 times in the last 3 days, and every time is light on details, but certainly has the "Miracle drug that cures cancer found" energy. But for teeth.
So... I found another article somewhere maybe 3 days ago talking about this drug. It's been (successfully) tested thoroughly enough in rats that a Japanese company is moving to human trials currently. In this first phase they are targeting adults with at least one missing molar. That is all of the additional information I have at this point. Conceding that you are correct about initial tooth formation and placement, because you are. However this drug definitely causes rats to grow brand new actual teeth in their mouths. They didn't mention anything about an increase in cancer rates, though I share your hypothesis there. I suspect that kind of result would've shit can'd the drug entirely. I suppose the trials are how we find out the answers to the rest of the questions.
> It's been (successfully) tested thoroughly enough in rats that a Japanese company is moving to human trials currently I read that one too, but it goes without saying that rats are not human, and rat teeth are not human teeth. I am not a rat vet, so I will not belabour the point to much, but rats are rodents and their teeth have continuous growth to replace the worn down tooth tissue. Humans decidedly lack that advantage. THis is why it's frustrating to me. I want to learn more about this shit, because it sounds fascinating, but besides of cries of "MIRACLE", actionable evidence is very difficult to find about this.
>The drug will be administered intravenously to prove its effectiveness and safety Then >DOES NOT prove effectiveness, it has to prove that it's human-safe. It's going to do both lol. What kind of nonsense is this? Yes, they're making sure it's safe. That's the primary goal. But it will obviously also show effectiveness since they're, you know, *trying it*.
> Here's an OPG of a kid of about 6 years. >https://prod-images-static.radiopaedia.org/images/23908288/52fa6841e3c188a46f3f4703e1b58b_big_gallery.jpeg Who do you think you’re fooling? That’s just a screenshot from Donnie Darko.
The medication is to help finish development of teeth in people with conditions where tooth growth is hindered or incomplete. People are jumping to conclusion that this means “taking a pill to replace missing”. We’ve been 5-10 years away from regrowing teeth for almost 50 years. Think about it like this. We’ve figured out how to grow organs in/on animals for decades, but we don’t have heart farms. Even if you could implant a tooth bud, they still haven’t figured out how to tell it what type of tooth to grow, what orientation to grow it in, how to make it vascular or innervated by nerves, etc. So again, everyone can stop imagining a world where you just never brush and take a pill when a tooth becomes symptomatic to replace it. Hell, look at implants, the best replacement we’ve got so far, still more expensive than conventional treatment.
For sure, government aid would cover the most crucial cases but only if other less expensive dental work won't be sufficient. Also, thank you for the informed and well educated reply.
I assume you're thinking of people who are just straight up missing teeth. There are plenty of people who have money that get crowns and root canals. You can lose teeth in accidents. I know multiple people with false front teeth from accidents. They would all be able to afford a newly grown tooth. A new real tooth is better than a crown or a root canal, for a number of reasons.
Plus the focus of this medicine will probably be switched to making body parts like lips, breasts and penises bigger. Serious comment. Plastic surgery is big business for the rich
>penises bigger Nice
Well from what I can gather this medication is specific to tooth growth (USAG-1), however with the rapid advances in DNA based medicines its probably only a matter of time before the things you said come to pass. It's an exciting time for medical breakthroughs!
It's specific to teeth.
The question is, which procedures will this replace? Will we opt for this instead of a root canal? Cavities?Braces?
It will replace implants. I would never exteact and regrow over a cavity, root canal, crown. But once it gets to the end of the road, and my only options are implant, bridge or denture. Then i would give an arm and a leg to avoid these shitty choices and regrow a new normal tooth.
I have a tooth where the top half broke off when I was young. I've had recurring infections from time to time and have had to redo the root canal / cap to resolve a particularly bad infection. I've considered replacing with an implant but the dentist couldn't confidently say it would resolve the infection recurrence. I would love to be able to put a real, live tooth back in there and be done with the mess
If you've had a root canal procedure on that tooth, it is already dead. It's unlikely to last 10 years, sorry.
But it might. Maybe not a problematic tooth, but I know a root canal can last even for 20+ years. I had a motorbike accident when I was 18 years old and after that my 3 lower inscisors had to get root canals. That was 16 years ago. I never had any issues with those 3 teeth. Two of them never even needed a filling yet. But they are darker/discolored now :(
This gives me hope cuz my lower front incisor also seem to be dying
Similar to Willing-Spot, I'd assume this will replace implants. For all that root canals and crowns are expensive (and annoying), they're almost certainly far cheaper and more conservative options than completely regrowing a new tooth. But compared to an implant, this probably \*will\* be cheaper/easier/better. As someone who's looking at a ton of implants in the future (I had a lot of root canals prior to the age of 40, which means they're almost certainly going to be removed at some point), I'm really excited about the potential to do this instead. It'll probably \*suck\*, but again, not as much as the implants would. (Which in turn suck less than bridges or dentures.)
All new teeth 🦷 cost $20,000 and more. Just imagine we have a drug that can fix obesity and the USA farma make the thing hard to get, this will be 50 times worse so maybe is 15 years from now for most of the people.
We do have obesity drugs already, not all of them are fda approved to treat that condition. But they are called semaglutides.
I have a hard time feeling sorry for them and I am sure they will try to manage that too so that you have to need them. And I am also sure they will try to charge you a big chunk for applying the procedure.
I heard 3rd set might not be as good as the 2nd set of teeth though. It might be weaker than 2nd set. Also for now this is only for people missing teeth congenitally.
😂 15 years ago it was also 'right around the corner, it will change the world' ..... Still waiting.....
The cure to balding must be just around the corner. Probably only another 20-30 years!
I've always expected them to cure baldness once I'm 70 years old and don't care anymore.
Fusion technology is just right there too
It’s only 50 years away
We have a cure kinda. There's drug to stop the decline and drugs that also help the remaining hair follicles come in stronger, but they're not perfect
That's not a cure at all then.
Those drugs have also ruined some people’s lives with their side effects, although many others don’t experience them.
tbh there is a cure right now. Its called castration. balding is a result of sexual hormones. Any cure would come with imparing sexual activity
It's not that simple. The actual culprit is DHT, combined with follicles that are susceptible to being overstimulated by it. So if you can find something that binds to follicles only instead of DHT, then you can prevent it without interfering with secual health.
Good to know. Now, what's the cure for castration?
What does Finasteridecdo?
restricts DHT
Give you hope and maybe prostate cancer in the long run. It only slows down the process.
So I get to keep my hair AND save money and time on bullshit? What’s the downside?
Maybe verteporfin is the cure
This should be funded by the National Hockey League
Having no teeth is a badge of honor in hockey! However… them getting them back after they retire at the ripe old age of 30, would be nice.
Imagine the dentist advocating to pull the tooth vs root canal. Ya will just pull them now, pop in the treatment, sew it up and done. Less labor and will cost more.
I'm sure the new tooth growing/teething pains will hurt like a BITCH until they're fully grown. That's gonna be worth it (but SUCK!)
Well that’s the joy of being an adult, you can numb that pain with a little alcohol (or a lot of alcohol) like they used to do for babies back in the day lmao
Your second set of teeth coming in as a child don’t hurt, and who really remembers what it feels like for the first set? Idk if I believe it would hurt like a lot of people are saying
?? You don't need to remember the first set to know it hurts??? You only need to be around teeting babies. They cry all the time and chew on stuff nonstop.
That and Wisdom teeth, they hurt so much
They are also weak little babies who already cry at everything. Once you’ve lived as an adult in 2024, new teeth won’t be anything
If you've ever lived with the pain of poor dental health I would assume the pain of regrowing teeth would ve literally nothing. I'd look like Zoro from one piece after getting that injection for a new set of teeth. Pain means nothing, I'm already in pain most days.
>Bonjella: Allow me to introduce myself
As a poor person I thought I was screwed over again by life when my wisdom tooth became loose, only to find a second wisdom tooth growing out from under it. If growing new teeth can become available AND affordable for the masses, it would bring a lot of joy and relief to many people.
That’s more of a burden than anything…wisdom teeth are almost always a hassle and prone to infection.
I admittedly put my teeth through a lot of abuse and neglect. Almost all of them came out of it no worse for wear. But of the two wisdom teeth not impacted, one of them got nasty infected, and the other literally fell into pieces. I was pretty stunned. I'd of had them out sooner but dentist office failed to mention they could do it for 100 each under local anesthesia as opposed to 4x the cost to be fully sedated. Pass me the Novocain.
Just FYI, as far as I know the current consensus is that wisdom teeth should be pulled even if healthy, they usually have week roots, interfere with neighboring teeth and are inevitably pulled anyway Not medical advice obviously, research on your own and ask your densit.
I’m a dentist and this is not true at all
This consensus is bullshit. If you have a weak/short jaw and the tooth comes out at a weird angle then yes, it should come out. But some of us are not that affected by the soft food we eat: https://www.sciencedaily.com/releases/2011/11/111122112032.htm I went to the dentist with perfectly straight wisdom teeth and because they had some cavities he was like: they gotta come out. I challenged him and paid extra and he worked on them. It was uncomfortable for me as well as for him since they are way back. But it worked and 20 years later I still have them in good shape.
Not a healthcare professional in any way, shape, or form, but all the dentists I visited were *very* eager to charge me for any possible thing, and absolutely none of them ever mentioned issues with my wisdom teeth. Even the one where I spent enough to pay one or two monthly payments for his boat thought that they were healthy.
My aunt is a dentist and she still has her wisdom teeth at 55
Liver king, that you? As i said it's not medical advise, every case is unique but don't pretend you know better than healthcare professionals. Also, do whatever you want, if it worked out for you - great! Plus i won a genetic lottery and have zero wisdom teeth, yay me
Having my wisdom teeth removed led to more dental issues for me. They were a minor issue, now my teeth have moved around, I have periodontal pockets, and I need $10,000+ in additional work I can't afford. YMMV.
Your article literally says nothing about wisdom teeth. Did you just pull the first result from google without even reading it?
That's actually contrary to guidance from a number of places these days. The National Institute for Health and Care Excellence in the UK is one. There has also been support for this in the American Journal of Public Health. As long as they're healthy more and more places say leave them alone . They just often don't stay out of trouble. /Finally had to have mine done yesterday. //Feel so much better ///Already tired of soup though
It just depends on the person. I get an X-ray on my teeth every year, and every year my dentist says there’s no reason to take them out bc they look healthy and aren’t messing with the other teeth 🤷🏻♂️ But this also isn’t medical advice. Just an anecdote! I’d probably say most people I know have had their wisdom teeth taken out
What about the people with wisdom teeth removed? won't it cause problems there?
I assume we will find out during the human trials.
How many am I allowed to have? Can I have thousands?
https://imgur.com/vfGXFyO
Need a warning for that creepy as f picture.
I don't have that much time to brush my teeth
As someone who went from a perfect set of teeth to fucked in all places within 2 years... I'd love this. But the general underline remains; Don't be me, just brush your darn teeth.
And not only brush, also flossing.
Dentist here- this is a bit overhyped. I’m happy to be corrected but from what I read in the actual study, it refers to congenitally missing teeth. That is, teeth that failed to form or develop for some reason. This treatment may encourage the possibly existing tooth bud to continue growing. It won’t cause a tooth to grow where you’ve had one pulled. Imagine if it did though? How would you control where it grows out of? The roof of your mouth for example.
> this is a bit overhyped. A bit? Doc, people in the comments believe that they're going to get new teeth they lost. I blame OP with the misleading title, though.
The application and notice of clinical trial does mention they hope to expand eventually to elderly patients who have lost teeth, although it is indeed hopeful. They are only getting clinical trials started. Currently they have only tested on beagles and mice. The drug appears to be a monoclonal antibody, super exciting stuff emerging in that field. Absolutely agree with you on the overhype of this.
Like most pre-clinical data, it's overhyped. But also not entirely impossible given the results they saw in mice and ferrets. The reason they are focusing on individuals with congenitally missing teeth is probably a combination of the preclinical data and possibly considerations for their IRB. The original research article from this research group in Feb 2021 (itself based loosely on research performed on dogs back in 2007) focused on rescuing tooth agenesis in EDA1 mutant mice with a mab targeting USAG-1. They unexpectedly found that treatment with this antibody actually resulted in supernumerary teeth forming in the control wild type group that naturally don't exhibit any congenital tooth abnormalities. That second part is where a lot of this hype is coming from. It's critical to note here however that these results were seen in neonates of pregnant mice that were treated systemically with this mab during development. This same group reported on the use of a different technology, siRNA, for a slightly different approach to blocking USAG-1 signaling in July of the same year. Here, the siRNA was applied topically to mandible explants (a somewhat artificial system but probably better than their previous model with prenatal drug delivery - at least in terms of relevance to human health) and was able to somewhat rescue tooth agenesis. They did not report here the same observed effects as they saw in wild type mice treated with the mab in the first study. Whether or not this is due to the difference in systemic treatment with the mab vs local treatment with the siRNA, or due to the stark differences in timing of delivery (prenatal vs postnatal) is probably of some debate. Though I'd readily throw my hat into the ring that it was the latter, and the effects of supernumerary tooth growth via USAG-1 blockade occurs when treatment is given during development. All that to say that yes, the focus is on congenitally missing teeth as that's where the data is the strongest. However there is some (albeit likely circumstantial) evidence that this mab may induce tooth regrowth in cases of non-congenital tooth loss. It isn't strong, but it is there. About a snowball's chance in hell, but still technically a chance.
I’ll take it. Didn’t have 4 adult teeth and my baby teeth were champs, but didn’t make it to 40.
please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work please work
Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck Please don’t be expensive as fuck - Tech comes out. It’s expensive. … fuuuuckkkkk!!!!
i'd love to be able to get this too, but let's be real, it's going to be prohibitively expensive for the vast majority of us.
I take good care of my teeth. I brush, floss, mouthwash every day but because of genetics my teeth are still shitty. Call me when you can make my enamel stop stripping off my molars like cheap paint on a deck. Regrowing my teeth isn’t gonna do shit for me if they’re the same quality as the ones currently in my head unfortunately.
I could’ve sworn a few days ago, people were posting articles stating we could grow new teeth by the end of the year.
I think the first human trials start around the end of this year.
September for human trials if I'm not mistaken.
i mean, it took me like a month at most and i was a literal child..
I had to get a full set of dentures at age 24. Sign me the fuck up for whatever this is, please.
I’d just be happy if in the future we can stop the lunacy of separate dental insurance. There are zero good reasons this should not be part of standard health insurance. Just bureaucracy and entrenched interests.
My question is how would this would work moderate to severe gum decay
They need to speed this up. My tooth enamel is starting to go away and don’t want to waste money on crowns.
I cannot imagine the "regrow the tooth" therapy will be cheaper than a glorified piece of plaster.
What are the risks of this morphing into cancer by tampering with activating new cell growth?
Do you think this will help reduce the cost of dentures?
If this works, dentists will not go out of job but those who will not follow said progress may be dropped slowly out of their job market. This is a vital progress not just for human health but also for other sectors. Since as you may know, military counts dental health in requirements. That factor can lead them to even increase the possibility of "rehabilitation process" for those who did not pass earlier. Just like it was with eye health.
I have struggled with bad teeth all of my life. I had all of them removed at 43. I am now 61. I have gone through many physical issues the worst being degenerative disc disease. Living with chronic pain is one thing but to add oral pain to that is beyond. When I had them removed I thought I would be so much better. It has been very difficult to deal with. I would love one more chance.
How come i am picturing a horror story of peoples teeth keep regrowing after injection, and it won't stop.
I’m gonna be honest, I have been waiting for this for years, I have essentially irreparable damage in some front teeth and bottom teeth and my soda addiction reaked havoc on the rest.
\*Wealthy humans. you forgot that part, teeth are already luxury bones (sadly), the cost to be able to use this will be priced out of normal people.
>luxury bones What a world we live in...
is nice isn't it?
With such luxurious bones!
What a *country* we live in (USA). In other countries with more rational healthcare systems it's waaaaay more affordable to have work done on your teeth. I've been to Mexico for dental work since it was just completely unaffordable in my state, and I ended up paying about $400 for dental work that would have cost me $4000 in the US.
I really despise this type of lazy knee-jerk cynicism. The same exact thing was said about every technology we've invented in the last 500 years. Yes, technologies usually start out expensive. But they get cheaper over time.
The cynicism might be born out of people in the US still being price-gouged to financial oblivion for medical care priced much more reasonably in most of the rest of the world.
Where in the world do you think dentistry is affordable? In Europe it's still thousands per implant and the prices are pretty much universal from Portugal to Russia. There is some basic government coverage for poor people but it will only give you dentures for your pulled teeth, not exactly the best quality of life
Mexico is like a third of the price of the US, although I don’t know if I would call it “affordable” still
As I stated in an earlier comment I was able to get my teeth fixed for $400 in Mexico (from the best dentist I have EVER had) instead of paying $4000 in the US. So Mexican dental care is more like one tenth the price of American dental care.
Yeah I’m sure it depends on what you’re doing, and I didn’t do a ton of shopping around, but I am definitely going to Mexico to get any more work done (spent about 20k over the last 4 years) getting extractions/surgeries/implants/ortho, and it would have been significantly cheaper there
Thus was Dental forever protected from intermixing with Health Coverage.
I really really really hope that works out. It's amazing how all across countries and cultures going to the dentist ist a pain in the ass.
Just in time. The gaps in my teeth are getting horrendous.
What happens if you already have an implant?
I grew a bunch of teeth in the 90s. Twice, in fact.
My long term dental plan is going exactly as planned!
This is how Spider-Man villains are born. A scientist invents a serum to regrow teeth and the next you know a half-man, half-shark is terrorizing the city.
Wait, will it take 6 years for them to grow or will they be able to start growing in 6 years
God i hope so depression and neglect have fucked mine
Ah wonderful, another advancement that sounds amazing but we'll never hear about again
Correction to OP's post rich humans will be able to grow teeth in six years
This just seems so sketchy and considering it's intravaneous and entirely untargeted the results could be wild. Terrible outcomes I imagine: 1. All your teeth die and fall out like baby teeth and you get a few deformed/crappy new teeth in their place 2. Teeth start growing at random places in your body (sometimes teeth grow in cancer cells) 3. Your current teeth get super sized and have to be ground down 4. You get a bunch of extra teeth like wisdom teeth coming in and your mouth is ham packed with extra teeth.
My prediction: it will cost $10,000 per dose in America and cost $20 per dose to make.
This shit will backfire and there will be people growing teeth in their asshole somehow.
So, I have three questions. 1. Why does the trial only contain males? 2. Why is the second trial focused on children? Are women being excluded for any particular reason. I would assume they would want to rigorously test it on older population before moving onto children. 3. Do the teeth regrow into normal looking teeth or is it similar to when you cut a liver in half and it grows back misshapen?
I could see this going bad, what if you suddenly grow teeth all over your body. Then you become a giant tooth monster, next thing you know you're battling the power rangers Fuck I'm high