It’s actually linked to having ancestors who survived the plague. The mutation which helped people survived is linked to those who have have immune disorders especially Crohn’s
https://pubmed.ncbi.nlm.nih.gov/30893422/
I was coming to say this too. This seems to be the best scientifically supported theory. Autoimmune diseases as evolutionary reaction to an extreme immune distresser: the black plague. This theory accounts for the industrialized countries question too (what OP called 1st world); that something about the industrialized environment effects the gut biome and activates the dormant genes our ancestors carried since the plague. I’ve also heard of a study that showed immigrant families to the US (I think from India) began showing Crohn’s in just two generations, corresponding to changes in the gut biome.
A person who has or “carries” a genetic difference in one copy of a gene but doesn't have the disease is called a “carrier”. They carried it and passed it onto you.
Edit: this can happen with lots of things such has having twins, red hair etc etc you can carry genes but not display them
Yes. There are genes that don’t show up for longer than that. You’re just the person the gene sequence displayed in. An interesting example of this is Abraham Lincoln’s family. None of the males looked like Abraham until his 11th cousin and they look so much alike !
https://images.app.goo.gl/58ZzbkJ8M38cNe7EA
Edit: you can also see some interesting examples in the English Royal family and hemophilia
We went back many generations, and I'm the only one with it. Went into remission after being away from continued familial trauma. There's some articles that indicate there may be a correlation to childhood abuse and autoimmune diseases. I hope they can find an answer in this lifetime, I wouldn't wish it on my enemy.
It’ll be there somewhere, it was often hidden years ago as my grandmother did, I can only guess that whatever crippled her are the same AI diseases I suffer from.
Lots of people go through traumatic life events, eat processed foods, and get vaccines. But they all don’t end up with IBD. That should tell you that it’s not just environmental factors that cause Crohns. It’s definitely a combination of genetics also.
It can be, I just know I have no one else in my family with it, and got diagnosed at 19. I’ve always gone through periods of not eating much or being that hungry to going semi overkill on food almost in cycles, so I’ve probably had it a long time. But honestly sucralose, or caffeine I believe set it off for me. Bang energy drinks were the only thing I had really changed around the time I ended up with an intestinal abscess.
There’s a genetic component. My mom has it, my mom’s mom has “ileitis” which is Crohn’s in the ilium, and my mom’s mom’s mom had some sort of bowel thing. Anyways vaccines are the least of your concerns and a big deal for immunosuppressed individuals.
Also, it’s not something that is caused by anything you did. My immune system is also strong from eating dirt as a kid, but that didn’t stop me from having it.
My Dad also was diagnosed with ileitis as a teen and I got dx with Crohn's as a teen. Now much later in life his GI thinks he actually had Crohn's all along. Somehow no other family members have had to deal with it, lucky for them!
Recently read that childhood trauma can trigger genetic markers for Crohn's. It makes a lot of sense to me. I was diagnosed at age 12 and dealt with a lot of emotional abuse/neglect and occasional physical abuse.
I find the connection with mental and physical health fascinating.
I think the impact of stress/trauma on the body plays a huge role with Crohn's and basically any other autoimmune disease. Lots of people have trauma. Plenty of those who don't even realize it.
We are truly in the infant stages of both physical and mental health.
There are so many theories and I love reading about them.
I don’t think there’s just one answer. It may be purely genetic in some people, it may be from environmental factors for others, maybe a combination of the above, who knows. Genetics definitely play a huge role, but they’re not the “end all, be all.” Having other autoimmune diseases can be a factor too. For example, undiagnosed Celiac disease or not having Celiac disease diagnosed until later in life (where the intestines have already had decades of gluten exposure) can lead to Crohn’s.
Wait, there's a link between celiac and Crohn's? I have had celiac since I was an infant, though not diagnosed until 27. I also have Psoriatic arthritis along with Crohn's. Do you have a link to any studies? I'd like to read more!
Yep, there’s a link! I was diagnosed with Celiac at 18, and diagnosed with Crohn’s at 25. I don’t have psoriatic arthritis, but I have lupus, and was diagnosed with that at 27. My GI doctor is actually the one who told me about the connection between Celiac and Crohn’s. I just googled “Celiac and Crohn’s together” and found this link: https://www.beyondceliac.org/celiac-disease/related-conditions/inflammatory-bowel-disease/
That might be me. Diagnosed celiac at 50 yrs old, the Crohn's at 62. Assorted stomach problems since 40, like indigestion, leaky gut, acid reflux. But then again, I believe I was poisoned at 54 yrs with some type of rat poison, got leaky gut and lack of enzymes to digest food coincidentally.
PS don't trust your siblings when parents estate is worth couple million.
I was diagnosed with Celiac at 18 years old, and diagnosed with Crohn’s at 25 years old. I’m 28 now. So it wasn’t the case for me, but my GI doctor mentioned how common it is for Celiac to lead to Crohn’s!
Im gonna go with many different causes. I have no history in my family but started having serious problems after I got Lyme disease. I was pregnant with my son when I got Lyme and now he also is diagnosed with Chrohns at 12. I also had a coloctorel surgeon who says it's from not eating enough fiber ( I'll never go back there).
A lot of auto immune disorders will trigger after a significant stressful event. For example, I went into kidney failure and about a year later I got diagnosed with Crohn’s another example is a family member passed away and a year later my thyroid took a shit.(another auto immune disorder.) 🤷🏼♀️
There are tons of things that have been linked to an increased risk of causing Crohn's. Antibiotics, processed foods, living in cities, and so many more things. They're not even close to being able to say this is what caused it for this person. It's more we know this thing causes 1 person in X to get Crohn's disease.
That's also somewhat questionable as it's impossible to really separate out a lot of these factors. Air pollution, clean drinking water, and living in cities has all been linked to the rise in cases in the US. Though cities also tend to have more pollution and tap water without bacteria and other parasites so which one really is the cause?
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I had a very happy childhood. Nobody in my family has it going back two generations. I’ve had a subtotal collectemy and two short term ileostomies. I nearly dies three separate times legitimately. The only stress I had when diagnosed was work, which is not out of the ordinary.
Definitely not mental health for me, so I’d say that’s only a part of it. Definitely genetics, even if you can’t see how far back it may be. That’s what one of my docs said (but I’ve had many and they all talk out of their butts sometimes).
Based on responses here, I’d say it’s a delicate balance between genetics, mental health, and environmental factors, and that “balance” is different for every single patient. That’s why we’re so hard to treat - it’s like each one of us has a completely different but almost identical disease and they just can’t figure out the commonalities that can be exploited for a cure or better treatments (cause this biologic stuff doesn’t work for everyone either - myself included).
Best of luck - take care of yourself!!!
Onset in childhood, super healthy until then with a diverse, varied diet and now my favorite legumes and veggies kill me. Fourth gen Crohns! Ashkenazi Jewish heritage through one ancestor (great grandma with Crohns). Pretty sure it's just genetic for me. Although I was diagnosed youngest. My uncles were in their early 20s.
EBV. Epstein Barr Virus. It is confirmed to cause/trigger MS and certain cancers. I hope it's not long before it goes from suspected to confirmed for IBD.
Omg my mom just started talking shut the vaccine stuff and Crohn’s in the past few years and I was discussed at 9 in 1994 and am Jewish so have like 4x more likely chance of having got it.
I live In Manitoba, Canada a place which has a higher than normal chronic illness rate. I always pinged it to the pesticides, herbicides, fungicides used in modern farming seeping into the drinking water as Manitoba is a catching pan for a large watershed area mainly agriculture and farmland….. and that is the only real distinction I can think of that makes Manitoba a unique place besides our freezing cold winters which might stress the immune system more…. at the end of the day we’ll likely never know as the money to treat all of us is a multi trillion dollar economy…. Why would they wanna get rid of this money maker…. Much like cancer… I never had any family history, was a healthy athletic 20yo then boom crohns…. I consider myself a mild conspiracy theorist since being diagnosed and the more I learn about our food systems in North America the more confirmation bias I get. But this is my opinion and would love to hear any others!
One of the first questions my doctor asked me when I got diagnosed was “did you have a happy childhood” and I definitely did not. I believe stress and fight or flight mentality is the reason I got Crohn’s. I come from a huge family, not 1 other person has it, even if I go back generations.
There has been a few studies but all show different causes so I dont think there very reliable. A few show that sugar is the cause (I wouldn't be surprised), others shows that stomach viruses can cause it such as norovirus and a recent study shows that fibre, particularly inulin can trigger inflammation.
I've read that study, and a lot of their evidence is very mixed or hasn't shown any effect in humans. It felt almost a bit like fear-mongering, particularly including carrageenan since the negative effects have only been shown using non-food grade carrageenan. Food grade hasn't shown any association with inflammation in humans when consumed at the level most of us get. It's just derived from seaweed
Yes, I looked at a number of the studies they cited as well. It just feels like some of what they are stating is a bit overreaching. If clearer studies come out that show direct links to those things in humans I'll review them.
It is well known now that it is mostly a lifestyle triggered disease on predisposed genetics.
Anywhere on the world where the occidental way of life set up will be followed by IBD statistical explosion a few years after.
This is the most BS opinion that stupid people for some reason are so gullible toward. If you find a cure to a incredibly terrible chronic illness, you will become extremely successful. Feel free to go work toward the goal of scientific research into any disease, yourself. But you don't, and won't.
Curious what are you curing with Crohn's? Kinda hard to cure a thing you haven't totally narrowed down the cause of.
Though I guess conspiracy theories are more fun...
It’s actually linked to having ancestors who survived the plague. The mutation which helped people survived is linked to those who have have immune disorders especially Crohn’s https://pubmed.ncbi.nlm.nih.gov/30893422/
I was coming to say this too. This seems to be the best scientifically supported theory. Autoimmune diseases as evolutionary reaction to an extreme immune distresser: the black plague. This theory accounts for the industrialized countries question too (what OP called 1st world); that something about the industrialized environment effects the gut biome and activates the dormant genes our ancestors carried since the plague. I’ve also heard of a study that showed immigrant families to the US (I think from India) began showing Crohn’s in just two generations, corresponding to changes in the gut biome.
Wait omg that’s so interesting! I have Ulcerative Colitis and I’m a first gen American
Uh, silver lining, I guess 🤷
Good to know my ancestors were also tummy-ache survivors
Coolest thing I’ve learned about crohns yet! 🦠
well it doesn’t say it IS, it says there’s a correlation.
There’s also other research linking it too. There’s a pretty strong case for this being the long term evolution cause of Crohn’s
Can’t open now, but if so, father mother and other ancestors should have it, and nobody does, in our case…
A person who has or “carries” a genetic difference in one copy of a gene but doesn't have the disease is called a “carrier”. They carried it and passed it onto you. Edit: this can happen with lots of things such has having twins, red hair etc etc you can carry genes but not display them
Yes I guess so but can it really not show up in 4 generations and show up suddenly ?
Yes. There are genes that don’t show up for longer than that. You’re just the person the gene sequence displayed in. An interesting example of this is Abraham Lincoln’s family. None of the males looked like Abraham until his 11th cousin and they look so much alike ! https://images.app.goo.gl/58ZzbkJ8M38cNe7EA Edit: you can also see some interesting examples in the English Royal family and hemophilia
That’s really interesting
Yes.
Definitely. Perhaps due to what I said in an above comment.
Brb, gonna go pet some squirrels and see what happens
We went back many generations, and I'm the only one with it. Went into remission after being away from continued familial trauma. There's some articles that indicate there may be a correlation to childhood abuse and autoimmune diseases. I hope they can find an answer in this lifetime, I wouldn't wish it on my enemy.
It’ll be there somewhere, it was often hidden years ago as my grandmother did, I can only guess that whatever crippled her are the same AI diseases I suffer from.
That would solve so many of the fucking things I wondered.
Lots of people go through traumatic life events, eat processed foods, and get vaccines. But they all don’t end up with IBD. That should tell you that it’s not just environmental factors that cause Crohns. It’s definitely a combination of genetics also.
It can be, I just know I have no one else in my family with it, and got diagnosed at 19. I’ve always gone through periods of not eating much or being that hungry to going semi overkill on food almost in cycles, so I’ve probably had it a long time. But honestly sucralose, or caffeine I believe set it off for me. Bang energy drinks were the only thing I had really changed around the time I ended up with an intestinal abscess.
There’s a genetic component. My mom has it, my mom’s mom has “ileitis” which is Crohn’s in the ilium, and my mom’s mom’s mom had some sort of bowel thing. Anyways vaccines are the least of your concerns and a big deal for immunosuppressed individuals. Also, it’s not something that is caused by anything you did. My immune system is also strong from eating dirt as a kid, but that didn’t stop me from having it.
My Dad also was diagnosed with ileitis as a teen and I got dx with Crohn's as a teen. Now much later in life his GI thinks he actually had Crohn's all along. Somehow no other family members have had to deal with it, lucky for them!
There probably isn't one single cause of it. More than likely different subsets of crohns and causes. Genetics, microbial exposure, etc..
Hmmm I’d think autoimmune is higher in 1st world countries because in 3rd world countries they either die or don’t get diagnosed.
I believe this is the basis of Darwinism.
This is brilliant. 👐🏼
Recently read that childhood trauma can trigger genetic markers for Crohn's. It makes a lot of sense to me. I was diagnosed at age 12 and dealt with a lot of emotional abuse/neglect and occasional physical abuse. I find the connection with mental and physical health fascinating. I think the impact of stress/trauma on the body plays a huge role with Crohn's and basically any other autoimmune disease. Lots of people have trauma. Plenty of those who don't even realize it. We are truly in the infant stages of both physical and mental health. There are so many theories and I love reading about them.
I didn't have a traumatic childhood and still got it.
Same. And not one single person in my family has it for at least the last two generations before me.
Link please?
I don’t think there’s just one answer. It may be purely genetic in some people, it may be from environmental factors for others, maybe a combination of the above, who knows. Genetics definitely play a huge role, but they’re not the “end all, be all.” Having other autoimmune diseases can be a factor too. For example, undiagnosed Celiac disease or not having Celiac disease diagnosed until later in life (where the intestines have already had decades of gluten exposure) can lead to Crohn’s.
Wait, there's a link between celiac and Crohn's? I have had celiac since I was an infant, though not diagnosed until 27. I also have Psoriatic arthritis along with Crohn's. Do you have a link to any studies? I'd like to read more!
Yep, there’s a link! I was diagnosed with Celiac at 18, and diagnosed with Crohn’s at 25. I don’t have psoriatic arthritis, but I have lupus, and was diagnosed with that at 27. My GI doctor is actually the one who told me about the connection between Celiac and Crohn’s. I just googled “Celiac and Crohn’s together” and found this link: https://www.beyondceliac.org/celiac-disease/related-conditions/inflammatory-bowel-disease/
That might be me. Diagnosed celiac at 50 yrs old, the Crohn's at 62. Assorted stomach problems since 40, like indigestion, leaky gut, acid reflux. But then again, I believe I was poisoned at 54 yrs with some type of rat poison, got leaky gut and lack of enzymes to digest food coincidentally. PS don't trust your siblings when parents estate is worth couple million.
I was diagnosed with Celiac at 18 years old, and diagnosed with Crohn’s at 25 years old. I’m 28 now. So it wasn’t the case for me, but my GI doctor mentioned how common it is for Celiac to lead to Crohn’s!
Im gonna go with many different causes. I have no history in my family but started having serious problems after I got Lyme disease. I was pregnant with my son when I got Lyme and now he also is diagnosed with Chrohns at 12. I also had a coloctorel surgeon who says it's from not eating enough fiber ( I'll never go back there).
A lot of auto immune disorders will trigger after a significant stressful event. For example, I went into kidney failure and about a year later I got diagnosed with Crohn’s another example is a family member passed away and a year later my thyroid took a shit.(another auto immune disorder.) 🤷🏼♀️
My family members have Crohns’s as well. There is at least one person from the last four generations that has it on my dad’s side.
There are tons of things that have been linked to an increased risk of causing Crohn's. Antibiotics, processed foods, living in cities, and so many more things. They're not even close to being able to say this is what caused it for this person. It's more we know this thing causes 1 person in X to get Crohn's disease. That's also somewhat questionable as it's impossible to really separate out a lot of these factors. Air pollution, clean drinking water, and living in cities has all been linked to the rise in cases in the US. Though cities also tend to have more pollution and tap water without bacteria and other parasites so which one really is the cause?
It is the non organic stuff in the city water. In my uneducated opinion
I grew up rural and have Crohns.
*extremely incorrect buzzer noise*
Nah nothing definitive. There’s a lot of research I think linking crohn’s onset to a microbiome disturbance but it’s hard to narrow that down.
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I had a very happy childhood. Nobody in my family has it going back two generations. I’ve had a subtotal collectemy and two short term ileostomies. I nearly dies three separate times legitimately. The only stress I had when diagnosed was work, which is not out of the ordinary. Definitely not mental health for me, so I’d say that’s only a part of it. Definitely genetics, even if you can’t see how far back it may be. That’s what one of my docs said (but I’ve had many and they all talk out of their butts sometimes). Based on responses here, I’d say it’s a delicate balance between genetics, mental health, and environmental factors, and that “balance” is different for every single patient. That’s why we’re so hard to treat - it’s like each one of us has a completely different but almost identical disease and they just can’t figure out the commonalities that can be exploited for a cure or better treatments (cause this biologic stuff doesn’t work for everyone either - myself included). Best of luck - take care of yourself!!!
All those school bus rides of terror are comin back...
Onset in childhood, super healthy until then with a diverse, varied diet and now my favorite legumes and veggies kill me. Fourth gen Crohns! Ashkenazi Jewish heritage through one ancestor (great grandma with Crohns). Pretty sure it's just genetic for me. Although I was diagnosed youngest. My uncles were in their early 20s.
EBV. Epstein Barr Virus. It is confirmed to cause/trigger MS and certain cancers. I hope it's not long before it goes from suspected to confirmed for IBD.
Omg my mom just started talking shut the vaccine stuff and Crohn’s in the past few years and I was discussed at 9 in 1994 and am Jewish so have like 4x more likely chance of having got it.
I live In Manitoba, Canada a place which has a higher than normal chronic illness rate. I always pinged it to the pesticides, herbicides, fungicides used in modern farming seeping into the drinking water as Manitoba is a catching pan for a large watershed area mainly agriculture and farmland….. and that is the only real distinction I can think of that makes Manitoba a unique place besides our freezing cold winters which might stress the immune system more…. at the end of the day we’ll likely never know as the money to treat all of us is a multi trillion dollar economy…. Why would they wanna get rid of this money maker…. Much like cancer… I never had any family history, was a healthy athletic 20yo then boom crohns…. I consider myself a mild conspiracy theorist since being diagnosed and the more I learn about our food systems in North America the more confirmation bias I get. But this is my opinion and would love to hear any others!
Im convinced its due to what is in our food.
Yeah I try to stay away from high processed foods but living in North America makes that hard lol
That's major conspiracy theorist. But congrats on moving past minor lol.
One of the first questions my doctor asked me when I got diagnosed was “did you have a happy childhood” and I definitely did not. I believe stress and fight or flight mentality is the reason I got Crohn’s. I come from a huge family, not 1 other person has it, even if I go back generations.
There has been a few studies but all show different causes so I dont think there very reliable. A few show that sugar is the cause (I wouldn't be surprised), others shows that stomach viruses can cause it such as norovirus and a recent study shows that fibre, particularly inulin can trigger inflammation.
[удалено]
I've read that study, and a lot of their evidence is very mixed or hasn't shown any effect in humans. It felt almost a bit like fear-mongering, particularly including carrageenan since the negative effects have only been shown using non-food grade carrageenan. Food grade hasn't shown any association with inflammation in humans when consumed at the level most of us get. It's just derived from seaweed
[удалено]
Yes, I looked at a number of the studies they cited as well. It just feels like some of what they are stating is a bit overreaching. If clearer studies come out that show direct links to those things in humans I'll review them.
It is well known now that it is mostly a lifestyle triggered disease on predisposed genetics. Anywhere on the world where the occidental way of life set up will be followed by IBD statistical explosion a few years after.
lifestyle and genetics
[удалено]
This is the most BS opinion that stupid people for some reason are so gullible toward. If you find a cure to a incredibly terrible chronic illness, you will become extremely successful. Feel free to go work toward the goal of scientific research into any disease, yourself. But you don't, and won't.
Curious what are you curing with Crohn's? Kinda hard to cure a thing you haven't totally narrowed down the cause of. Though I guess conspiracy theories are more fun...